HLA Presentation of Cancer Neoantigens from Mutations

Learning Objectives:

• Explain how HLA alleles interact with cancer mutations to create individual differences in anti-tumor immunity that affect patient outcomes.
• Discuss immunopeptidomics in combination with genomics for pMHC target discovery and protein engineering techniques for targeting non-immunogenic peptides on MHC.
• Evaluate the implications of tumor-specific HLA loss in cancer and methods to detect gene-specific loss in situ.