Workshop 5: 50+ Years of HLA Antigen, Allele, and Antibody Nomenclature: Moving Toward Integrated and Consistent Approaches for Clinical Practice

Speaker(s)

• 

  Marcelo Fernandez-Vina, PhD, F (ACHI)

  Stanford University
• 

  Steven Marsh, PhD, FRCPath

  Anthony Nolan Research Institute
• 

  Jerry Morris, MD, PhD, A(ACHI)

  University of California San Diego

Moderator(s)

• 

  Steve Mack, PhD

  UCSF
• 

  Doreen Sese, CHS

  NYU Langone | Transplant Institute

This session will review historical and current processes for achieving standardized Nomenclature of HLA factors. The need for periodic updates will be discussed, with special focus on current gaps resulting from outdated serological nomenclature The rationale for developing criteria for the definition of HLA antigens in silico will be presented. The resulting updates in assigning serologic antigens corresponding to the vast majority of HLA alleles defined by molecular methods will be presented. Implementation of these updates for their use in Clinical Histocompatibility practices will be discussed.

Session developed by Marcelo Fernandez-Vina, Steve Mack, Jerry Morris and Doreen Sese, program planning committee.

Presentations:

• 2:46 PM – 3:15 PM US PDT

  History of HLA antigen/allele nomenclature
  

  Speaker: Steven GE Marsh, PhD, FRCPath – Anthony Nolan Research Institute
• 3:15 PM – 3:45 PM US PDT

  The Clinical Challenge of Imprecise Nomenclature for HLA Serology
  

  Speaker: Jerry Morris, MD, PhD, A(ACHI) – University of California San Diego
• 3:45 PM – 4:15 PM US PDT

  Serotypes - What They Are, Why They’re Needed, and How We Can Utilize Them
  

  Speaker: Marcelo Fernandez-Vina, PhD, F (ACHI) – Stanford University