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Workshop

Workshop 1: Back to Basics: Deep Dive into Antigenicity, Immunogenicity, and Alloantibody Formation

Tuesday, October 22, 2024
2:45 PM – 4:15 PM US PDT
Location: Marquis Center

With multiple approaches to assess HLA eplets and molecular mismatches, there is intense interest in improving the sensitivity and biological relevance of these models by identifying those most likely to stimulate an alloimmune response. This is widely being called “immunogenicity,” but the definitions and biology of antigenic vs. immunogenic properties need to be considered as we move forward. This session will cover features of antigens that make them more or less able to be recognized by T/B cells, then discuss the role of antigen presenting cells and their activation state as determinants of adaptive immune activation. Lastly, we will translate these premises to the biology of B cells and alloantibody production.

Session developed by Carey Killion and Nicole Valenzuela, program planning committee.

Presentations:

  • 2:46 PM – 3:15 PM US PDT
    Defining Immune Epitopes for Antigen Recognition and Presentation

    Speaker: Alba Grifoni, PhD – La Jolla Institute for Immunology

  • 3:15 PM – 3:45 PM US PDT
    Antigen Presenting Cells: How innate cells sense “danger,” present antigen, and shape the adaptive immune response

    Speaker: Helen Goodridge, PhD – Cedars-Sinai Medical Center

  • 3:45 PM – 4:15 PM US PDT
    How B Cells Discriminate Self from Non-self and Become Primed for Antibody Production

    Speaker: David Nemazee, Ph.D. – Scripps Research