Keynote Address: ABO Histocompatibility: New Tools to Explore ABH Antigens and ABO Antibodies in the Transplant Setting

Speaker(s)

• 

  Lori West, Professor

  University of Alberta

  Handouts

Moderator(s)

• 

  Anne Halpin, PhD, A(ACHI)

  University of Alberta
• 

  Cathi Murphey, PhD, HCLD/CC(ABB), A(ACHI)

  SWID

Understanding ABO-histocompatibility will allow improved risk assessment for ABO-incompatible organ transplantation. This presentation will cover emerging glycomics tools to improve accuracy of risk assessment. The ABO glycan microarray and ABO single antigen bead luminex assay for detection and precise characterization of ABO subtype specific antibodies will be especially helpful. Additionally, ABO subtype-specific monoclonal antibodies and ABO genotyping will allow full donor and recipient profile and tissue-specific antigen expression. These tools can accompany crucial information generated by HLA risk assessment.

Session developed by Rob Liwski, program planning committee chair.

To learn more please click here.