Plenary IV: Implementation of Precision Medicine Approaches to Reduce Alloimmune Injury and Prolong Kidney Allograft Survival

Speaker(s)

• 

  James Lan, MD, FRCPC, D(ACHI)

  University of British Columbia
• 

  Paul Keown, MD, DSc, MBA, FACP, FASN, FAST, FRCP, FRCPC, FRCPath, FRSC, FRSB

  University of British Columbia
• 

  Ana Konvalinka, MD, PhD, FRCPC

  University Health Network, University of Toronto

Moderator(s)

• 

  Patricia Campbell, MBChB, FRCPC

  Alberta Precision Labs (Retired)
• 

  Jenny Tran, PhD

  Vancouver Coastal Health

This session will highlight three precision medicine approaches aimed at understanding, preventing, and treating alloimmune injury which remains a dominant cause of long-term kidney allograft loss. Presenter 1 will demonstrate novel approaches to understand the functional properties of donor specific antibodies and their interaction with the kidney allograft tissue. Presenter 2 will show the clinical utility of using molecular mismatch analysis to risk stratify and guide the selection of induction therapy. Presenter 3 will discuss the approach and activities undertaken to incorporate molecular matching in local and national kidney allocation systems in Canada.

Session developed by Anne Halpin, James Lan, Rob Liwski and Cathi Murphey, program planning committee.

Presentations:

• 4:15 PM – 4:45 PM US PDT

  Utilizing Proteomic Based Platforms as Biomarkers for Allograft Injury, Dysfunction and/or Rejection
  

  Speaker: Ana Konvalinka, MD, PhD, FRCPC – University Health Network, University of Toronto
• 4:45 PM – 5:15 PM US PDT

  Implementation of Eplet Mismatch Analysis to Inform Induction Therapy in Kidney Transplantation
  

  Speaker: James Lan, MD, FRCPC, D(ACHI) – University of British Columbia
• 5:15 PM – 5:45 PM US PDT

  National Implementation of Precision Medicine in Transplantation
  

  Speaker: Paul Keown, MD, DSc, MBA, FACP, FASN, FAST, FRCP, FRCPC, FRCPath, FRSC, FRSB – University of British Columbia