University of Colorado School of Medicine
The Norman lab studies immune diversity across worldwide populations. They also study ancient humans and perform comparative evolutionary analyses of multiple other species. The group focuses on the co-evolution of HLA and KIR, which are Natural Killer (NK) cell receptors that interact with HLA to control immune cell activity. Characterized by extreme sequence and structural diversity, HLA and KIR are encoded by the most complex, and amongst the most medically important, regions of the human genome. Through population genetics and molecular analyses that inform functional experiments, the aim is to determine precisely how genetic variation can influence immunity and immune-mediated disease. Prof Norman did his postdoctoral training at Stanford, before becoming a Laboratory Head at the University of Colorado in 2018. He has over 115 publications including multiple high impact works, and almost 10,000 citations. Paul has been a Lymphoma Society Research Fellow, and currently holds numerous NIH and private funded grants.
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Featured Topic: Immunogenetics & Disease
Monday, October 21, 2024
12:30 PM – 5:00 PM US PDT
Archaic KIR3DL1 enhances HLA binding to inhibit NK cells throughout Oceania
Monday, October 21, 2024
3:40 PM – 4:10 PM US PDT