Monash University
Prof. Rossjohn is known for his contributions to understanding the molecular basis underpinning immunity. He has used structural biology to explain how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T- cell reactivity. He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen. In 2022, Prof. Rossjohn was elected as a Fellow of the Royal Society.
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Featured Topic: Immunogenetics & Disease
Monday, October 21, 2024
12:30 PM – 5:00 PM US PDT
TCR Recognition of Lipids and Metabolites
Monday, October 21, 2024
3:10 PM – 3:40 PM US PDT